Proteins

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Proteins

What are proteins for?

The DNA sequences carried in each cell are blueprints. They are the instructions that tell the cell how to be part of an animal, plant, fungus or bacterium. Virus genes tell other cells how to make more viruses! The majority of genes are instructions that tell cells how to make proteins. Proteins are the active elements of cells. They aid and control the chemical reactions that make the cell work. They receive signals from outside of the cell. They control the processes by which proteins are made from the instructions in the genes. They also form the scaffolding that gives cells their shape and as well as parts of the linkages that stick cells together into tissues and organs.

Many drugs (both medicinal and illegal!) alter the work done by proteins. There are also a number of important diseases that are the direct result of mistakes in a genes sequence. These mistakes happen when the DNA is being copied and are passed on to the descendants of the creature in which the copying error was first made. Diseases such as Sickle Cell Anaemia, Cystic Fibrosis and Muscular Dystrophy come from this type of copying error or mutation. Cancer is caused by copying errors that occur in the lifetime of a creature that break down the control of cell growth. Order Custom Essay on proteins

How Are Proteins Made?

Proteins, like DNA, are complicated molecules made up by sticking simple building blocks together in a chain. The Proteins are made of more types of building blocks than DNA. 0 kinds of amino acids are involved in making most proteins. Each type of amino acid can perform a different job. Some act like scaffolding, some keep the protein dissolved in water and others take part in the chemical processes that the protein controls.

The next great discovery in genetics, after the structure of the DNA molecule, was the way in which the sequence of DNA bases on the chain carry the information on how to make proteins. The cell first makes a copy of the DNA instructions. The DNA instructions contain a region which controls how often a copy is made. The copy is made of a different type of nucleic acid called RNA.

The RNA copy is moved to the protein making machinery in the cell which is called the ribosome. Every set of three RNA bases in a row control which amino acid is to be added to a growing protein molecule. A special three base code (usually ATG) tells the ribosome where the instructions on how to make the protein begin in the sequence. The copy of the DNA chain passes through this protein making machinery like a tape through a tape player. The ribosome, however, produces protein instead of sound!

How Does DNA Work?

DNA is a chain built up of four simple building blocks. The four types are adenine, cytosine, thymine and guanine or A, C, T and G for short. The shapes of A and T and of C and G are complementary. Each of the two pairs fit together neatly like pieces of a jigsaw puzzle. The two chains of the DNA structure stick together due to bonds which form between the complementary pairs of bases. It is the complementary base pairs that allow DNA to copy itself.

Under certain circumstances the two chains of the DNA molecule separate. New DNA bases come in and stick to their complementary partner on the existing chain. The new bases are then stuck together to make a daughter DNA chain. This process occurs for each of the original chains of the parent DNA molecule. Two daughter DNA chains are, therefore, formed.

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Maple syrup

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Maple syrup…you are probably saying to yourself right now "Oh yeah I've tasted that before", or "Oh yeah I know that stuff", but what you don't know is this is a barrier which shields you from the real stuff. This will lead you in to the sweet wonderful world of maple syrup and turn your head away from the fake industrialized maple syrup and allows you have a glimpse of what you are really missing.

True maple syrup is golden brown with a delightful smell which takes your breath away. One drop on your tongue is all it takes for you to get hooked; you might even call it the cocaine of desserts. Most people would say that they can describe what maple syrup tastes like with only two words "Mmm and Yum". Although maple syrup can be very fattening there is nothing like it, there is no substitute for maple syrup.

Maple syrup can be eaten with a variety of foods such as pancakes, bacon, fried eggs, desserts, cookies, etc. Yeah you're probably saying to yourself right now "How can I eat bacon and eggs with maple syrup! They just don't go together". Many people I knew thought the exact same thing, for example Maddie Moore who used to go to Ho Chi Minh City School. I was eating breakfast with her and we had bacon and eggs. I poured maple syrup on it and she said that that was disgusting until she tried it for herself and she just got hooked. She couldn't get enough of that stuff.

As the saying goes "If you want something, you have to work for it". Well that is totally true in this case because maple syrup is very hard to make. It is very time consuming. The tools which are needed are a drill with a 7/16- or 1/-inch bit for drilling tap holes in trees; metal or plastic collection spouts for each tap hole and a large container; a large pan to boil the sap. (The size needed will depend on how much sap you intend to handle.); a large-scale thermometer calibrated at least 15 degrees above the boiling point of water; wool for filtering finished syrup while hot; and a bottle to store the syrup. Buy cheap maple syrup term paper

The very first thing you have to do is make tap holes in the maple tree. You drill a hole into the tree and insert a tap. Then you attach a plastic tube to open buckets for the collection of the tree sap. In one day on average you can collect one quart to one gallon, depending on the conditions. Producing maple syrup is essentially a matter of concentrating the sugar solution to a predetermined level through evaporation. Heat is used to concentrate the sap and to develop the characteristic maple color and flavor that make maple syrup so highly desirable. You will put the sap into the pan and heat it. The boiling point of maple syrup is 107 degrees Celsius and the temperature must be carefully monitored and the sap must be stirred constantly to ensure the heat distribution is even and so it doesn't get burnt.

Maple syrup is very hard to obtain. Why could anyone be bothered to sit in front of a very hot pan and stir for hours and hours just for some lousy syrup? Well, that is one of the things about maple syrup; it is so good it drives people to go through pain and hardship just for the taste. As I said before it is like the cocaine of desserts and nothing can be a substitute for it. Ask anyone if they have tasted maple syrup before and from how they reply you can tell if they have tasted real maple syrup or the fakze maple syrup.

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Lord of the Flies

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Part A The Truth About Talking

In Ben Johnson's quote "Language most shows a man? Speak, that I may see thee!" He tries to explain his theory. This quote explains that when a person says anything we can understand his personality by the context in which he said it. I agree with Ben Johnson's quote because the way in which someone speaks sometimes shows more about their personality than their actions would. The characters from the following novels best exemplify this quote Jack and Ralph from William Golding's Lord of the Flies, and Juror , from Reginald Rose's novel Twelve Angry Men.

In William Golding's Lord of the Flies, Ralph is honorable in principles, intentions, and actions. He is realistic and democratic in his leadership role. When the boy's first become stranded on the island Ralph has to truthfully tell all of the younger boys about their situation by saying,

"'The plane was shot down in flames. Nobody knows where we are. We may be here a long time.'" (4). At meetings Ralph is very democratic and insists on keeping order and rules. Ralph is addressing the boys and telling them what they need to accomplish in order to survive and to be saved. Ralph proves his leadership when he says, "'There aren't any grownups. We shall have to look after ourselves'…. ' And another thing. We can't have everybody talking at once. We'll have to have a "Hands up" like at school'…. ' Then I'll give him the conch.'" (). Ralph is always logical and realistic; he knows what has to be done in order to obtain their objective of being saved. He shows this when Jack goes hunting and takes the boys who were supposed to be watching and keeping the fire going. Ralph confronts Jack by saying, "'There was a ship. Out there. You said you'd keep the fire going and you let it out! They might have seen us. We might have gone home'" (70). Order College Papers on Lord of the Flies

In Reginald Rose's Twelve Angry Men, Juror is an opinionated man who proves to be very intolerant of other people's opinions. Juror 8 is trying to plant reasonable doubt into the other juror's minds and some of the jurors are beginning to be swayed by his arguments. Juror shows his sadistic feelings when he says to the other jurors

You come in here with your heart bleeding all over the floor about slum kids and injustice and you make up these wild stories, and you've got some soft-hearted old ladies listening to you. Well I'm not, I'm getting real sick of it. What's the matter with you people? This kid is guilty! He's got to burn! We're letting him slip through our fingers here (100).

Juror is very intolerant of others opinions and he forces those opinions on all of the other jurors. Juror 8 was explaining how the old man could have lied about hearing the boy yell to his father "I'm going to kill you" and he was planting reasonable doubt into some of the jurors minds. Juror shows his intolerance when he says to the other jurors, "Well, that's the most fantastic story I've ever heard. How can you make up a thing like that? What do you know about it?" (8). Juror cannot believe that Juror 8 is changing everyone's opinion because he believes so vehemently that the boy is guilty. Juror has an extremely opinionated mind and he believes that everything he says is the most important. Everyone in the jury had been convinced that the boy was not guilty but Juror shows he still wasn't convinced by telling the jurors, "Well you're not going to intimidate me! I'm entitled to my opinion! It's gonna be a hung jury! That's it!" (108).

In William Golding's Lord of the Flies, Jack is very controlling and sometimes violent. Throughout the novel Jack proves to be unpredictable and at times cruel. The boys are talking about the beast and the littluns are speaking up about how scared they are. Jack proves his cruelty and his non-understanding when he states, "'You don't hunt or build or help you're a lot of cry-babies and sissies. That's what. And as for fear - you'll just have to put up with it like the rest of us.'" (8). Jack is overly confident and at times arrogant. Jack has an aura of authority around him and that makes it easier for him to act like the leader. When all of the boys have their first meeting they decide that they need to choose a chief who will make all the decisions for the group. Jack speaks up by addressing the group of boys on his opinion he says, "' I ought to be chief, because I'm chapter chorister and head boy. I can sing C sharp'" (). Jack seems very confident that he will receive every vote for chief and that contributes to his disappointment after he doesn't get elected. Later in the novel Jack shows his desire to command and control everything and everyone. After the majority of the boys join Jack's tribe he rules over them commanding the boys to do things for him. He treats everyone as though they were lower than him and that he is better than all of them. He shows this authoritarian character when he speaks to the boys, "'Give me a drink.' Power lay in the brown swell of his forearms authority sat on his shoulder and chattered in his ear like an ape. 'All sit down.'" (150).

I agreed with Ben Johnson's quote because I feel that a person can reveal everything about himself when he talks. This includes his personality and how he treats people. The characters and quotes supported Johnson's quote because all of them revealed their true self in what they said.

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Scrooge

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). This story takes place in London, England. The time is winter and it starts the day before Christmas, also known as Christmas Eve. The settings of the book include Scrooge's Counting House, Scrooge's Home, Bob Cratchit's home, assorted places throughout Scrooges childhood like the schoolhouse and the Fizziwig's place where Scrooge was an apprentice, this is where a Christmas party took place and he met the one love of his life. Then it skips to Scrooge's love of his life when she is married and they speaks about Scrooge and how he is now in a world of his money. Also it shows the exchange, homeless people under a bridge, and a cemetery.

.) The four main characters in the book are Ebenezer Scrooge, Tiny Tim, Bob Cratchit, and Ebenezer Scrooge's nephew, Fred.

First, lets examine Ebenezer Scrooge, since he is the main character of the story, All ghosts visit him. Through him, the lesson of the story is to be learned. In the book, he is made out to be Anti-Christmas and he is constantly commented about by characters in the book, some feeling pity, others feeling hostility.

External heat and cold had little influence on Scrooge. No warmth could warm, no wintry weather chill him. No wind that blew was bitterer than he…Nobody ever stopped in the street to say, with gladsome looks, 'My dear Scrooge, how are you? When will you come to see me?'. No beggars implored him to bestow a trifle, no children asked him what it was o'clock, no man or woman ever once in all his life inquired the way to such and such a place, of Scrooge. (Dickens 14).

Next there is Tiny Tim, he seems to be a symbol of hope in this story even though he has to use a crutch to walk and he is very small. Despite his disability, he constantly keeps the spirit up and tries to maintain it in all his brothers, sisters, and parents, even though they are poor. He is the epitome of the Christmas spirit, that which should inhibit all of us. He told me, coming home, that he hoped the people saw him because he was a cripple, and it might be pleasant to them to remember, upon Christmas Day, who made lame beggars walk and blind men see. (15). This quote just shows how thoughtful he is, and how much he cares for others.

Tiny Tim's father Bob Cratchit is next on my list. He is an employee of Scrooge and he is the only one in the Cratchit family to thank him genuinely for the job and the pay that he has given him to support his family and keep food in their stomachs. …and in came little Bob, the father, with at least three feet of comforter, exclusive on the fringe, hanging down before him, and his threadbare clothes all darned up to look seasonable, and Tiny Tim upon his shoulder.(11). The father's love for his family bleed through the fact that they are poor and Scrooge sees this in the way they act.

The last but not least major character is Scrooge's nephew, Fred. He seems to be the only individual who comes to converse with Scrooge and offer him anything. In this case, Fred offered him an invitation to his house for Christmas dinner. Fred is convinced at the beginning of the story that Scrooge doesn't really mean Bah!…Humbug! (18) no matter how many times he says it. Fred is presented cheerful and in high spirits. He had so heated himself with rapid walking in the fog and frost, this nephew of Scrooge's, that he was all in a glow; his face ruddy and handsome; his eyes sparkled, and his breath smoked again. (18). As I said before, Fred is one of the few that feels pity for Scrooge.

.) The book starts off talking about Jacob Marley, Scrooge's former business partner. It basically says that he was dead as a door-nail (11). Then it moves to Scrooges counting house where he converses with Fred. Then two men come in to ask for a donation and Scrooge shoos them away quickly enough. Then Bob Cratchit come in for a days work and Scrooge is stingy about putting coal on the fire. At this point in the book, Scrooge is not made out to be a nice, caring, giving man. When Scrooge goes home, he is confronted by the ghost of Marley who tells him that he will be haunted by three spirits over the course of the next three days, each at One O'clock. The first spirit that comes is the Ghost of Christmas Past. This spirit takes Scrooge back to his childhood where he sees a very lonely boy engulfed in his books without a friend. Then they skip ahead in time and see when Scrooge was an apprentice to Mr. Fizziwig. This episode shows the Christmas party that Old Fizziwig threw and here is where he met the love of his life. Once again the ghost skips ahead to a time when Scrooge and the woman are speaking. She says that she has been replaced by a golden idol and there is not any room for her anymore. After this, the first Ghost leaves. The next ghost, the Ghost of Christmas Present as come to show him how his hostility toward others affect the way people live. The majority of the trip takes place at the Cratchits home. Here, Scrooge sees Tiny Tim's hope and the togetherness of the family. I personally think this scene is one of the most important in convincing Scrooge to change. Then Scrooge is transported to his nephew Fred's house where he is having his Christmas party. He then sees that even his nephew mocks him. Then the ghost takes him to what would be considered the bad part of town, under a bridge. There he sees a truly poor family, this one without a home. Even here the family stays together and refuses to be broken up, despite their disposition. The Ghost of Christmas Present leaves and then he encounters the Ghost of Christmas Yet to Come. This ghost is very mysterious, never talking. It merely points with it's long, narrow fingers. The scene again is the Cratchits, this time sorrow instead of joy. Tiny Tim has died and the family mourns his pasing. Bob just returned from the cemetery and comments about how beautiful it is. Next the ghost shows how the people of the town react to a man's death. No one seems to care about the loss of this wretched human being. Even some people steal his belongings out from under his dead body in his own bed. Scrooge does not realize they are all talking about him until the ghost takes him to the cemetery when Scrooge sees his own gravestone. From this point on Scrooge begs the ghost to let him change his lifestyle and try to change it for the better. When Scrooge wakes up he realizes that it is Christmas Day. He starts his new life of good will by buying a prize goose for the Cratchits. Then he makes a donation to the men that he shooed away the day before and he joins his nephew Fred for his Christmas dinner and Tiny Tim lives!

4). The first ghost, The Ghost of Christmas Past- This apparition comes to Scrooge to show him where his pain is coming from and when he turned his life toward the direction of money. The spirit was …like a child; yet not so like a child as like an old man , viewed through some supernatural medium, which gave him the appearance of having receded from the view, and being diminished to a child's proportion. It's hair…was white, as if with age; and yet the face had not wrinkled…It wore a tunic of purest white; and round it's waist was bound a lustrous belt, the sheen of which was beautiful. (6). The second ghost, The Ghost of Christmas Present- This ghost shows how Scrooge's lifestyle has affected the people who he has contact with. Every man and woman that knows him or knows of him have a set idea of him. A mean, old, stickler. The spirit was …clothed in one simple, deep-green robe, or mantle, bordered with white fur.(107). He had a holly wreath, a scabbard without a sword, and dark-brown curls. The third ghost, The Ghost of Christmas Yet to Come- This third ghost was very mysterious, Scrooge made most of the conclusions during this time himself, although very self-explanatory. I personally think that this apparition carried the most weight in changing Scrooge. It made him greatly sorry for his sinful behavior of his past and vowed to change his life. Not much was said about the spirit except that it was dressed darkly and did not speak, only pointed.

5). The message that Dickens is trying to get across is one of happiness. If you live your life in seclusion, only speaking to those who you must and always being nasty, you can never be truly happy. Dickens uses Scrooge as the epitome of selfishness and we are suppose to realize this and contrast it with Tiny Tim's attitude of caring and sharing. He is the epitome of joy and hope. He is the person in the book with who we are suppose to learn from. The ghost are the conduit from which we are to understand the past, present, and future of an unhappy man.

6.) Life in the 1800's was one of simplicity, everyone seemed to know each other in their area. People lived and worked in their neighborhood, which brought a greater sense of community and family values. Some Christmas customs were hanging candles from a tree instead of ornaments. Holidays always seemed to be a gathering of people to celebrate the occasion. The dress in the time period seemed to be top hats, slacks, vest, and a coat. From the movie that we watched, the style seemed very formal. When speaking to another person, it was speaking in proper English, never a 'Yo' or a 'Whaz up'. This is because of the time period and the slang we use now had developed with our generation. Although very different, it is very ,much alike. A Christmas Carol was a very good book and a lesson to be learned by all, and in the words of Tiny Tim, God Bless Us, every one (10) !

Merry Christmas!

Matt Toback

English

Period

December 0, 16

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The Advantage and Disadvantage of studying overseas

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Nowadays studying overseas has came into fashion,a lot of people are trying to go abroad at the expense of everything ,it seems once you are abroad,everything will turn out to be wondeful.Is studying abroad the only way to achieve success? I dont think so 1

although studying overseas can enlarge your vision but sometimes,do you really think it worth the great expense?For example,if you are living a very good life,you just want to try a better one,then by going abroad ,you might even lose your present happiness,bucause,you have to face a new and strange cindition in foreign countries.If you cant adapt yourself successfully to it ,you may feel lonely,even ,miserable.Nostalgia has always been a great problem for those who are living on a foreign land.

And ,in my opinion,only in ones mother-land can one have real success,It may be easier to lead a materially better life abroad than at home,but this does not mean that forengn country for long may not be a pleasant experience,You may get rid of the language barriers,but even after that ,you may still be a cultural outside.

Lets look at the reality,how many people have achieved their success abroad ?Is that all the people gong abroad are successful?The answer is of course no

Write your The Advantage and Disadvantage of studying overseas research paper

Just like the coin has two sides ,studying abroad also

has the advantages and disadvantage.

Inspit of that ,the advantages overweight disadvantage,so ,It is valuable to studying abroad.

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Smoking

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It is the single most preventable cause of death and disease. It causes more deaths than cocaine, auto accidents, alcohol, fire, AIDS, suicide, and homicide combined (The Foundation for a Smoke Free America). Can you guess what I am talking about? It is smoking, and it is killing many people. Why would you want to smoke if it causes so many deaths? People have all kinds of excuses for that question. Some of which include "I'm stressed out", "I need to lose weight", and " I just want to fit in". Would you want to die because you wanted to lose weight, you felt stressed, or you just want to be cool? There are many reasons you should not start smoking and why you should stop smoking now. It is causing pain and suffering not only to the smokers, but also to people who don't even smoke.

Why do people start smoking? Every person has their own excuse about why they started and why they don' t want to quite smoking. Many of the excuses can be treated without smoking. If you want to lose weight, try working out. If you are stressed, see your doctor for medication. If you just want to fit in, try being nice. Smoking is not the cure for any reason to start smoking. Tests have shown that when you stop smoking you only gain about five pounds, but the average weight gain for those who continued to smoke was one pound (The Foundation For a Smoke Free America). So think about it, if you stop smoking you'll gain a few pounds, but if you continue to smoke you still gain more weight each time you smoke. Therefore, smoking is not a cure it's an excuse.

There are many costs involved with smoking. We are not only talking about money, but your life. In the United States alone, smokers are spending approximately fifty billion dollars a year on cigarettes. Take this for an example, if Marlboro's prices were to stay at $. a pack, as they currently are, and someone smoked an average of two packs a day. In a month, they would have spent $1.80 and in a year they would have spent $,40.0. Isn't there something besides cigarettes that people could spend their money on? People are dying for food in our own country and many people are just worried about smoking those two packs of cigarettes each day. According to the Foundation for a Smoke Free America, the costs to our society includes over four hundred thousand lives lost every year in the United States, which is approximately eleven hundred each day. It was estimated by The Foundation for a Smoke Free America, that 500million out of 1. billion smokers would die because of smoking in the world. That means that nine percent of the people who are presently living in the world will die from smoking this year. Have you ever thought that you could be nine percent who die from smoking?

There are many affects smoking has on the human body. It causes several diseases and even death. Some of the complications cigarettes have on our bodies includes wheezing, coughing, colds, earaches, asthma attacks, itching and watering of the eyes, pneumonia, bronchitis, emphysema, lung cancer, and it destroys the smell and taste of food. These are only a few of the complications that cigarette smoke has on the actual smoker. Smoking also causes second hand smoke. This is extremely harmful to our society. People who don't even smoke are facing some of the consequences cigarettes cause. According to CDC, second hand smoke can produce six times the pollution of a busy highway when in a crowded restaurant. It also fills the air with many of the same poisons found in the air around toxic waste dumps. CDC also stated, second hand smoke causes up to three hundred thousand lung infections in infants and young children each year. These affects that smoking has on human bodies is extremely amazing. Can you believe that people still want to smoke; even when they are well aware of the consequence it has on their life and body? The label on each pack of cigarettes has a warning stating a few of the harmful affects of smoking cigarettes.Order custom research paper on Smoking

The hardest thing for a smoker to do is to quit smoking. There are many methods to help you try and stop smoking. Some of which include acupuncture, cold turkey, hypnotherapy, laser treatment, clinic based programs, and gradual quitting. People usually don't stop smoking right off the bat. Many people go through the non-smoking process many times before they actually stop smoking. It is a long process that can be very stressful on a smoker. Many smokers have a variety of withdrawal symptoms. The Foundation for a Smokefree America reported that withdrawal symptoms include irritability, fatigue, insomnia, occasional dizziness, difficulty concentrating, hunger, and craving for cigarettes. Many people cannot handle these withdrawal symptoms and a relapse occurs. There are a few reasons that relapses occur. Some of which include stress, withdrawal symptoms, boredom, and peer pressure. The Foundation for a Smoke Free America suggests that if a relapse does occur that the smoker recognize that it is a small set back, but it doesn't mean that they are a smoker again, learn from the setback, and don't look back on what has occurred, look at what you are trying to accomplished, and stay focused.

There are many benefits that come along with you when you decide that you need to quit smoking. The Foundation for a Smoke Free America says that some of the immediate benefits include a decline in carbon monoxide levels in the blood, heightened sense of taste and smell, and better oral health. Smoking does not cure anything it actually causes diseases. There is no excuse for smoking, so why start.

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Tolerance Develops to the Sympathomimetic But Not the Local Anesthetic Effects of Cocaine

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Wilson, Lance. et al. 000. Tolerance Develops to the Sympathomimetic But Not the Local Anesthetic Effects of Cocaine. Journal of Toxicity Clinical Toxicology. Vol 8 (7) 71.

The objective of this study was to obtain the effects of cocaine in the tolerance development of the sympathomimetic and the tolerance development to the local anesthetic. Twelve mixed-sex mongrel dogs, with the mean body weight of 17.7 kg were randomized to receive six, 5.5 mg/kg doses of cocaine. Arterial pressure, electrocardiogram, and serum cocaine were measured at control group, then at fixed time intervals of 15 minutes after each doses of cocaine or placebo. Each dog was given an intramuscular injection of morphine sulfate, 1.5 mg/kg, for sedation and anesthetized with an intravenous injection of alpha-chloralose, 100mg/kg, dissolved in polyethylene glycol. Each dog was then randomized in to one of three groups. Each dog in the low-dose group received .5 mg/kg of cocaine in ten cc saline. Each dog in the high-dose group received 5. mg/kg of cocaine in ten cc saline. The dogs in the control group received ten cc of normal saline. All dogs were given six total doses of cocaine at 15-minute intervals. Just before each injection, blood samples were drawn from each dog and immediately placed in a chilled glass tube containing potassium oxalate and sodium fluoride. Blood concentrations were acquainted using capillary gas chromatography with a mass spectrometer using electron ionization in a selected ion-monitoring mode as a detector. The major observed changes in mean arterial pressure were significant decrease in the high cocaine dose group lasting one to two minutes after each cocaine dose. After the third dosage, the maximal decrease of % in mean arterial pressure occurred two minutes. After the initial increase, there was a no significant increase in the mean arterial pressure. In the low cocaine dose group, there was a significant increase in the mean arterial pressure six minutes after the fourth cocaine injection. The mean arterial pressure increased 1% compared to the control group. There were no significant changes in mean arterial pressure in the control group. Both high-dose and low-dose cocaine caused prolongation of the intervals of the surface electrocardiogram. The sympathomimetic effects of cocaine include positive ionotropic, chronotropic, and hypertensive responses to cocaine and have been attributed to increased tissue catecholamine level

Wilson, Lance. et al. 000. Tolerance Develops to the Sympathomimetic But Not the Local Anesthetic Effects of Cocaine. Journal of Toxicity Clinical Toxicology. Vol 8 (7) 71.

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